Mole HER and Cel
نویسندگان
چکیده
Downlo ivated oncogenes are the dominant drivers of malignant progression in human cancer, yet little is known how the transformation from proto-oncogene to activated oncogene drives the expression of transd phenotypes. An isogenic model of HER-2–mediated transformation of human mammary epithelial as used along with HER-2–amplified human breast cancers to investigate how HER-2 activation alters perties as a signaling molecule and changes the networks of HER-2–regulated genes. Our results show ull oncogenic activation of HER-2 is the result of a transition in which activated HER-2 acquires ant signaling properties that qualitatively alter the network of genes regulated by the activated oncoompared with the proto-oncogene. Consequently, gene expression programs related to invasion, cell and stemness become regulated by HER-2 in a manner not observed in nontransformed cells, even stress, when HER-2 is overexpressed. Our results offer novel insights into biological processes that come under the control of HER-2 after it acquires full oncogenic potential. Cancer Res; 70(20); 7862–73. ©2010 AACR.
منابع مشابه
Ruptured Complete Hydatidiform Mole in the Fallopian Tube
Tubal pregnancies are common but presence of hydatidiform mole in tube is a rare entity. A woman of 53years presented with acute abdomen, preoperative pregnancy test was positive and ultrasonography suspected the case as hydatidiform mole in right tube. The patient was treated with total abdominal hysterectomy with bilateral salpingo-oophorectomy as her family was completed. Subsequent histopat...
متن کاملStructure of Polymeric Nanoparticles in Surfactant-Stabilized Aqueous Dispersions of High-Molar-Mass Hydrophobic Graft Polymers
Aqueous dispersions of hydrophobic high-molar-mass cellulose-graft-polystyrene (Cel-g-PS) copolymers were prepared by nanoprecipitation from dioxane solutions using sodium dodecyl sulfate as a stabilizer. The size and structure of formed Cel-g-PS nanoparticles were studied by scattering techniques (static and dynamic light scattering, SAXS) and transmission electron microscopy. The scattering a...
متن کاملBirth of a live fetus in twin pregnancy with hydatidiform mole and co-existent a live fetus: case report
Background: Twin pregnancy consist a healthy fetus, and hydatidium molar pregnancy is unusual and very rare. Its incidence is in about 1,22,000 to 1,100,000 of all pregnancies. This type of pregnancy is commonly associated with several obstetric complications requiring early termination of pregnancy. Managing a twin mole pregnancy with normal and live fetuses is controversial, although this unu...
متن کاملAssociation between adjunctive metformin therapy in young type 1 diabetes patients with excess body fat and reduction of carotid intima-media thickness.
INTRODUCTION Lipoprotein-associated phospholipase A2 (Lp-PLA2) and cholesteryl ester lipase (CEL) may oxidize low-density lipoproteins (oxLDL). OBJECTIVES The aim of the study was to determine the influence of metformin on the metabolism of atherogenic lipid fractions in relation to Lp-PLA2 and CEL levels, as well as assess consequent improvement in the intima-media thickness (IMT) of the...
متن کاملحاملگی
EXTRACT: Although all pregnant women are worry about their fetus, it is more serious in pregnant nurses. We are not talking about Hydatidform mole, Amniotic fluid embolism, and Sheehans syndrome. Fortunately these disorders are rare. Instead what are serious for a pregnant nurse are infection diseases, radioactive materials, anticancer agents, and other chemicals. Meanwhile when a nurse remove ...
متن کامل